The game comes just 24 hours after the Londoners sacked Mark Hughes as manager, with Harry Redknapp set to take over from the former United striker next week.
Wayne Rooney returns for United after missing the last two games with toncillitis and he joins Robin van Persie in attack. Darren Fletcher plays alongside Paul Scholes in the centre of midfield, with Danny Welbeck and Ashley Young making-up the front six.
Here are the confirmed line-ups:
Lindegaard; Rafael, Evans, Ferdinand, Evra; Young, Fletcher, Scholes, Rooney, Welbeck; van Persie.
Subs: De Gea, Jones, Anderson, Smalling, Hernandez, Cleverley, Powell.
Cesar, Mbia, Hill, Nelsen, Traore, Derry, Faurlin, Mackie, Taarabt, Dyer, Cisse.
Subs: Green, Diakite, Ferdinand, SWP, Granero, Ephraim, Hoilett