The Premier League leaders are red-hot favourites to progress with the winners booking a place in the quarter finals and with it a home tie against either Chelsea or Middlesborough.
Sir Alex Ferguson has rung the changes from the side that drew 1-1 with Real Madrid at the Bernabeu last week with Robin van Persie, Rio Ferdinand, Patrice Evra and Michael Carrick among those rested, with Javier Hernandez, Chris Smalling, Alexander Buttner, Ashley Young and Anderson coming in.
Here are the confirmed line-ups for the game:
De Gea, Smalling, Jones, Vidic, Buttner, Valencia, Anderson, Cleverley, Young, Welbeck, Hernandez
Subs: Lindegaard, Ferdinand, Carrick, Giggs, Nani, Kagawa, van Persie
Federici, Kelly, Shorey, Mariappa, Morrison, Karacan, Leigertwood, McAnuff, McCleary, Hunt, Le Fondre
Subs: Andersen, Gunter, Pearce, Carrico, Guthrie, Robson-Kanu, Pogrebnyak
Now we’ve seen the teams, what#’s your score prediction for the game? Leave your suggestions below.